f On the Nature of Poliovirus Genetic Recombinants
- Authors: P. D. Cooper, A. Steiner-Pryor, P. D. Scotti*, D. Delong†
- First Published Online: 01 April 1974, Journal of General Virology 23: 41-49, doi: 10.1099/0022-1317-23-1-41
- Subject: Articles
- Issue Published:
Recombinant and parental poliovirus particles were indistinguishable by ratezonal and isopycnic sedimentation, and by u.v. inactivation. Sensitive selective procedures, applied to ts + recombinants to detect genetic segregation of one parent, failed to reveal any. Poliovirus genetic recombinant particles thus appear to be conventional virus particles; their significance for recombination mechanisms is discussed. Sensitivity to the growth inhibitor 2-(3-chloro-p-tolyl)-5-ethyl-1,3,4-oxadiazole is shown to depend on a product of the structural protein gene.
Present address: Department of Developmental Biology, Research School of Biological Sciences, Australian National University.
Visiting Fellow from Lilly Research Laboratories, Indianapolis, Indiana.
© Society for General Microbiology, 1974 | Published by the Microbiology Society
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