Replication of Reticuloendotheliosis Viruses in Cell Culture: Chronic Infection
Temin, H. M. and Kassner, Victoria K.,, 27, 267-274 (1975),
doi = https://doi.org/10.1099/0022-1317-27-3-267,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= SUMMARY After an initial acute infection with cell killing, chicken or duck embryo fibroblasts infected in culture with reticuloendotheliosis viruses set up a chronic infection with no cell killing or morphological transformation. Essentially all of the chronically infected cells produced virus. The virus production was not sensitive to cytosine arabinoside or mitomycin C as was virus production in an acute infection. The chronically infected cells had a strong group-specific resistance to the c.p.e. of superinfecting reticuloendotheliosis viruses. However, they were sensitive to vesicular stomatitis virus and avian leukosis-sarcoma viruses. After double infection, single cells produced reticuloendotheliosis virus and avian leukosis-sarcoma virus.,
language=,
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