f Studies on the Nature and Genetic Control of an Antigen in Normal Chick Embryos which Reacts in the COFAL Test
- Authors: L. N. Payne, R. C. Chubb
- J. Gen. Virol., December 1968 3: 379-391, doi: 10.1099/0022-1317-3-3-379
- Subject: Articles
- Published Online:
Chick embryos from the inbred Reaseheath I line of chickens contained a complement-fixing antigen which reacted in the COFAL test, whereas embryos from the inbred Reaseheath C line lacked the antigen. In cross-bred embryos between the I and C lines the antigen segregated in accordance with the hypothesis that the presence of the antigen was controlled by a single autosomal dominant gene. The antigen appeared to be identical to the group-specific antigen of the avian leukosis-sarcoma group of viruses. No infectious virus was detected in I-line embryos, and the presence of the antigen was not correlated with response to the A and B subgroups of avian leukosis-sarcoma viruses. The possible relationship between the I-line antigen and viral group-specific antigen is discussed.
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