%0 Journal Article %A Payne, L. N. %A Chubb, R. C. %T Studies on the Nature and Genetic Control of an Antigen in Normal Chick Embryos which Reacts in the COFAL Test %D 1968 %J Journal of General Virology, %V 3 %N 3 %P 379-391 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-3-3-379 %I Microbiology Society, %X Summary Chick embryos from the inbred Reaseheath I line of chickens contained a complement-fixing antigen which reacted in the COFAL test, whereas embryos from the inbred Reaseheath C line lacked the antigen. In cross-bred embryos between the I and C lines the antigen segregated in accordance with the hypothesis that the presence of the antigen was controlled by a single autosomal dominant gene. The antigen appeared to be identical to the group-specific antigen of the avian leukosis-sarcoma group of viruses. No infectious virus was detected in I-line embryos, and the presence of the antigen was not correlated with response to the A and B subgroups of avian leukosis-sarcoma viruses. The possible relationship between the I-line antigen and viral group-specific antigen is discussed. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-3-3-379