f Inhibition of Influenza Virus Replication in Tissue Culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA): Mechanism of Action
- Authors: P. Palese, R. W. Compans*
- J. Gen. Virol., October 1976 33: 159-163, doi: 10.1099/0022-1317-33-1-159
- Subject: Articles
- Published Online:
The neuraminidase inhibitor 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA) inhibits the multicycle replication of influenza viruses in tissue culture. Influenza virus grown in the presence of FANA contains neuraminic acid on its envelope which then serves as receptor for other virus particles causing extensive aggregation. Thus, FANA inhibits influenza virus replication by preventing the enzymatic removal of neuraminic acid from the virus envelope.
Present address: Department of Microbiology, University of Alabama in Birmingham, Birmingham, AL 35294
© Society for General Microbiology 1976 | Published by the Microbiology Society
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