The Effect of Δ-9-Tetrahydrocannabinol on Herpes Simplex Virus Replication Blevins, R. Dean and Dumic, Michael P.,, 49, 427-431 (1980), doi = https://doi.org/10.1099/0022-1317-49-2-427, publicationName = Microbiology Society, issn = 0022-1317, abstract= SUMMARY Both herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) failed, in an identical fashion to replicate and produce extensive c.p.e. in human cell monolayer cultures which were exposed (8 h before infection, at infection, or 8 h p.i.) to various concentrations of Δ-9-tetrahydrocannabinol. Similar results were obtained with a plaque assay utilizing confluent monkey cells. Possible mechanisms for this antiviral activity are discussed., language=, type=