RT Journal Article SR Electronic(1) A1 Clerx, John P. M. A1 Casals, Jordi A1 Bishop, David H. L.YR 1981 T1 Structural Characteristics of Nairoviruses (Genus Nairovirus, Bunyaviridae) JF Journal of General Virology, VO 55 IS 1 SP 165 OP 178 DO https://doi.org/10.1099/0022-1317-55-1-165 PB Microbiology Society, SN 1465-2099, AB Summary Viruses from six antigenic groups of arthropod-borne viruses [Crimean-Congo haemorrhagic fever (CCHF), Nairobi sheep disease (NSD), Qalyub (QYB), Sakhalin (SAK), Dera Ghazi Khan (DGK) and Hughes (HUG) serogroups], some previously categorized as bunyavirus-like viruses and others previously ungrouped, have recently been assembled by serological analyses into a new genus of viruses (Nairovirus genus) in the Bunyaviridae. Molecular studies of the virion RNA and viral polypeptides have been undertaken with representative members of the different serogroups [Hazara (HAZ) and Congo (CON) viruses, CCHF group; Dugbe (DUG) virus, NSD group; QYB, Omo and Bandia (BDA) viruses, QYB group; Avalon (AVA) virus, SAK group; DGK and Abu Mina (AM) viruses, DGK group; and HUG virus, HUG group]. In agreement with a recent study of QYB virus and in part agreement with an earlier report on DUG virus, the results of these molecular analyses indicate that nairoviruses have: (i) three virion RNA species (large, L, medium, M, and small, S) with apparent mol. wt. of 4.1 × 106 to 4.9 × 106, 1.5 × 106 to 1.9 × 106 and 0.6 × 106 to 0.7 × 106 respectively; (ii) a 48 × 103 to 54 × 103 mol. wt. nucleocapsid (N) polypeptide; and (iii) two external glycopolypeptides, 72 × 103 to 84 × 103 mol. wt. (G1) and 30 × 103 to 40 × 103 mol. wt. (G2). Cross-immune precipitation analyses have confirmed that viruses in the Nairovirus genus share antigenic determinants and are antigenically distinct from representative members of the Bunyavirus, Phlebovirus and Uukuvirus genera (Bunyaviridae)., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-55-1-165