f Patterns of Cytopathology and Lysosomal Enzyme Release in Poliovirus-infected HEp-2 Cells Treated With Either 2-(α-Hydroxybenzyl)-Benzimidazole or Guanidine HCl
- Authors: L. E. Guskey, P. C. Smith*, D. A. Wolff
- First Published Online: 01 January 1970, Journal of General Virology 6: 151-161, doi: 10.1099/0022-1317-6-1-151
- Subject: Articles
- Issue Published:
The viral inhibitors guanidine hydrochloride and 2-(α-hydroxybenzyl)-benzimidazole (HBB) were used to study the relationship between lysosomal enzyme release and the development of poliovirus-induced cytopathic effect (CPE) in HEp-2 cells. Lysosomal enzyme release, the development of CPE and virus replication were inhibited or delayed if these antiviral agents were added up to 2 to 3 hr after infection. When added later the agents were no longer effective. It is suggested that a virus-induced protein produced during 3 hr after infection is responsible for lysosomal enzyme release.
Present address: Department of Veterinary Medicine, U.S. Army Medical Component, SEATO, APO 96346
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