%0 Journal Article %A Guskey, L. E. %A Smith, P. C. %A Wolff, D. A. %T Patterns of Cytopathology and Lysosomal Enzyme Release in Poliovirus-infected HEp-2 Cells Treated With Either 2-(α-Hydroxybenzyl)-Benzimidazole or Guanidine HCl %D 1970 %J Journal of General Virology, %V 6 %N 1 %P 151-161 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-6-1-151 %I Microbiology Society, %X SUMMARY The viral inhibitors guanidine hydrochloride and 2-(α-hydroxybenzyl)- benzimidazole (HBB) were used to study the relationship between lysosomal enzyme release and the development of poliovirus-induced cytopathic effect (CPE) in HEp-2 cells. Lysosomal enzyme release, the development of CPE and virus replication were inhibited or delayed if these antiviral agents were added up to 2 to 3 hr after infection. When added later the agents were no longer effective. It is suggested that a virus-induced protein produced during 3 hr after infection is responsible for lysosomal enzyme release. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-6-1-151