Patterns of Cytopathology and Lysosomal Enzyme Release in Poliovirus-infected HEp-2 Cells Treated With Either 2-(α-Hydroxybenzyl)-Benzimidazole or Guanidine HCl
Guskey, L. E. and Smith, P. C. and Wolff, D. A.,, 6, 151-161 (1970),
doi = https://doi.org/10.1099/0022-1317-6-1-151,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= SUMMARY The viral inhibitors guanidine hydrochloride and 2-(α-hydroxybenzyl)- benzimidazole (HBB) were used to study the relationship between lysosomal enzyme release and the development of poliovirus-induced cytopathic effect (CPE) in HEp-2 cells. Lysosomal enzyme release, the development of CPE and virus replication were inhibited or delayed if these antiviral agents were added up to 2 to 3 hr after infection. When added later the agents were no longer effective. It is suggested that a virus-induced protein produced during 3 hr after infection is responsible for lysosomal enzyme release.,
language=,
type=