RT Journal Article SR Electronic(1) A1 Guskey, L. E. A1 Smith, P. C. A1 Wolff, D. A.YR 1970 T1 Patterns of Cytopathology and Lysosomal Enzyme Release in Poliovirus-infected HEp-2 Cells Treated With Either 2-(α-Hydroxybenzyl)-Benzimidazole or Guanidine HCl JF Journal of General Virology, VO 6 IS 1 SP 151 OP 161 DO https://doi.org/10.1099/0022-1317-6-1-151 PB Microbiology Society, SN 1465-2099, AB SUMMARY The viral inhibitors guanidine hydrochloride and 2-(α-hydroxybenzyl)- benzimidazole (HBB) were used to study the relationship between lysosomal enzyme release and the development of poliovirus-induced cytopathic effect (CPE) in HEp-2 cells. Lysosomal enzyme release, the development of CPE and virus replication were inhibited or delayed if these antiviral agents were added up to 2 to 3 hr after infection. When added later the agents were no longer effective. It is suggested that a virus-induced protein produced during 3 hr after infection is responsible for lysosomal enzyme release., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-6-1-151