The Role of Liver in the Catabolism of Human α- and β-Interferon
Bocci, V. and Pacini, A. and Bandinelli, L. and Pessina, G. P. and Muscettola, M. and Paulesu, L.,, 60, 397-400 (1982),
doi = https://doi.org/10.1099/0022-1317-60-2-397,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= SUMMARY The susceptibility of human leukocyte (α), fibroblast (β) and recombinant α-2-interferons to clearance by the isolated and perfused rabbit liver has been evaluated. Human leukocyte and recombinant α-2-interferons were stable and their initial levels were maintained in the perfusate even if they had been treated with neuraminidase, thus suggesting that α-interferons have no exposed sugars recognizable by hepatic binding proteins. On the other hand, native, and particularly desialylated human β-interferon, underwent marked hepatic uptake confirming the importance of the liver as a catabolic site for glycosylated interferons.,
language=,
type=