f Neuronal Function Impairment in Rabies-infected Rat Brain
- By H. Tsiang
- First Published Online: 01 August 1982, Journal of General Virology 61: 277-281, doi: 10.1099/0022-1317-61-2-277
- Subject: Animal
- Issue Published:
In homogenates of rabies-infected rat brain the specific binding of a tritium-labelled antagonist of muscarinic acetylcholine (mACh) to mACh receptors (mAChR) varied during the course of infection. A small increase in the binding of the antagonist, quinuclidinyl benzylate (QNB), during the first days after infection was followed by a marked decrease as the symptoms of rabies appeared. Measurements of 3H-labelled QNB binding in dissected brain regions, i.e. brain stem, caudatus nucleus, cortex, hippocampus, cerebellum and medulla, showed that the decrease in binding was greater in the hippocampus than in any other brain region. We conclude that in the central nervous system (CNS) of the rabies-infected rat neuronal impairment may be one manifestation of rabies pathogenesis.
© Society for General Microbiology 1982 | Published by the Microbiology Society
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