f Genomic Location and Lack of Phosphorylation of the HSV Immediate-Early Polypeptide IE 12
- Authors: H. S. Marsden, J. Lang, A. J. Davison, R. G. Hope, D. M. Macdonald
- First Published Online: 01 September 1982, Journal of General Virology 62: 17-27, doi: 10.1099/0022-1317-62-1-17
- Subject: Animal
- Issue Published:
Herpes simplex virus type 1 (HSV-1) induces an immediate-early (IE) polypeptide IE 12. An equivalent polypeptide coded by HSV-2 which migrated slightly more slowly on SDS-polyacrylamide gels was identified and designated IE 12.3. Analysis of the serotype of the IE polypeptide induced by five HSV-1/HSV-2 intertypic recombinants when correlated with their genome structures showed that IE 12/IE 12.3 mapped in the region spanning the TRS/US junction. Unlike four other IE polypeptides induced by HSV-1 (IEs 175, 110, 68 and 63), IE 12 was not detectably phosphorylated.
© Society for General Microbiology 1982 | Published by the Microbiology Society
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