RT Journal Article SR Electronic(1) A1 Marsden, H. S. A1 Lang, J. A1 Davison, A. J. A1 Hope, R. G. A1 Macdonald, D. M.YR 1982 T1 Genomic Location and Lack of Phosphorylation of the HSV Immediate-Early Polypeptide IE 12 JF Journal of General Virology, VO 62 IS 1 SP 17 OP 27 DO https://doi.org/10.1099/0022-1317-62-1-17 PB Microbiology Society, SN 1465-2099, AB SUMMARY Herpes simplex virus type 1 (HSV-1) induces an immediate-early (IE) polypeptide IE 12. An equivalent polypeptide coded by HSV-2 which migrated slightly more slowly on SDS-polyacrylamide gels was identified and designated IE 12.3. Analysis of the serotype of the IE polypeptide induced by five HSV-1/HSV-2 intertypic recombinants when correlated with their genome structures showed that IE 12/IE 12.3 mapped in the region spanning the TRS/US junction. Unlike four other IE polypeptides induced by HSV-1 (IEs 175, 110, 68 and 63), IE 12 was not detectably phosphorylated., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-62-1-17