f An Immunoradiometric Assay of Serum Interferon using a Monoclonal Antibody
- Authors: J. R. Walker, J. Nagington, G. M. Scott, D. S. Secher
- First Published Online: 01 September 1982, Journal of General Virology 62: 181-185, doi: 10.1099/0022-1317-62-1-181
- Subject: Animal
- Issue Published:
An immunoradiometric assay for human interferon-α (HuIFN-α) has been adapted for the assay of low concentrations of HuIFN-α in human serum. The sensitivity of the assay is 5 to 10 IU/ml and the coefficient of variation less than 10%. The assay was shown to compare well with a biological (antiviral) assay in the measurement of serum interferon following intramuscular injection of HuIFN-α in nine volunteers. Serum interferon was also measured in the serum from 250 normal human donors. Two donors appeared to have detectable levels of HuIFN-α.
© Society for General Microbiology 1982 | Published by the Microbiology Society
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