@article{mbs:/content/journal/jgv/10.1099/0022-1317-64-1-247, author = "Davison, A. J. and Wilkie, N. M.", title = "Either Orientation of the L Segment of the Herpes Simplex Virus Genome May Participate in the Production of Viable Intertypic Recombinants", journal= "Journal of General Virology", year = "1983", volume = "64", number = "1", pages = "247-250", doi = "https://doi.org/10.1099/0022-1317-64-1-247", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-1-247", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "HSV", keywords = "inversion", keywords = "recombination", keywords = "homology", abstract = "SUMMARY We have analysed the genome structures of 90 recombinant viruses produced by co-infection of baby hamster kidney cells with the DNA of a herpes simplex virus type 1 temperature-sensitive mutant (tsD) and specific DNA fragments of wild-type herpes simplex virus type 2 at non-permissive temperature. Crossovers were located predominantly in regions of greatest intertypic homology, and we conclude that primary recombination occurred with the L segment of the genome in either orientation.", }