%0 Journal Article %A Davison, A. J. %A Wilkie, N. M. %T Either Orientation of the L Segment of the Herpes Simplex Virus Genome May Participate in the Production of Viable Intertypic Recombinants %D 1983 %J Journal of General Virology, %V 64 %N 1 %P 247-250 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-64-1-247 %K HSV %K inversion %K recombination %K homology %I Microbiology Society, %X SUMMARY We have analysed the genome structures of 90 recombinant viruses produced by co-infection of baby hamster kidney cells with the DNA of a herpes simplex virus type 1 temperature-sensitive mutant (tsD) and specific DNA fragments of wild-type herpes simplex virus type 2 at non-permissive temperature. Crossovers were located predominantly in regions of greatest intertypic homology, and we conclude that primary recombination occurred with the L segment of the genome in either orientation. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-1-247