Either Orientation of the L Segment of the Herpes Simplex Virus Genome May Participate in the Production of Viable Intertypic Recombinants Davison, A. J. and Wilkie, N. M.,, 64, 247-250 (1983), doi = https://doi.org/10.1099/0022-1317-64-1-247, publicationName = Microbiology Society, issn = 0022-1317, abstract= SUMMARY We have analysed the genome structures of 90 recombinant viruses produced by co-infection of baby hamster kidney cells with the DNA of a herpes simplex virus type 1 temperature-sensitive mutant (tsD) and specific DNA fragments of wild-type herpes simplex virus type 2 at non-permissive temperature. Crossovers were located predominantly in regions of greatest intertypic homology, and we conclude that primary recombination occurred with the L segment of the genome in either orientation., language=, type=