RT Journal Article SR Electronic(1) A1 Davison, A. J. A1 Wilkie, N. M.YR 1983 T1 Either Orientation of the L Segment of the Herpes Simplex Virus Genome May Participate in the Production of Viable Intertypic Recombinants JF Journal of General Virology, VO 64 IS 1 SP 247 OP 250 DO https://doi.org/10.1099/0022-1317-64-1-247 PB Microbiology Society, SN 1465-2099, AB SUMMARY We have analysed the genome structures of 90 recombinant viruses produced by co-infection of baby hamster kidney cells with the DNA of a herpes simplex virus type 1 temperature-sensitive mutant (tsD) and specific DNA fragments of wild-type herpes simplex virus type 2 at non-permissive temperature. Crossovers were located predominantly in regions of greatest intertypic homology, and we conclude that primary recombination occurred with the L segment of the genome in either orientation., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-1-247