@article{mbs:/content/journal/jgv/10.1099/0022-1317-65-5-859, author = "Davison, M.-J. and Preston, V. G. and McGeoch, D. J.", title = "Determination of the Sequence Alteration in the DNA of the Herpes Simplex Virus Type 1 Temperature-sensitive Mutant ts K", journal= "Journal of General Virology", year = "1984", volume = "65", number = "5", pages = "859-863", doi = "https://doi.org/10.1099/0022-1317-65-5-859", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-65-5-859", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "HSV-1 ts K", keywords = "marker rescue", keywords = "Vmw 175", abstract = "SUMMARY The alteration in the DNA sequence responsible for the mutant phenotype of the herpes simplex virus type 1 temperature-sensitive mutant ts K has been determined. A single C:G base pair present in the wild-type Vmw 175 immediate-early polypeptide-coding sequence has been replaced by T:A in the mutant gene. This results in the substitution of an alanine by a valine codon. In two revertants the mutant T:A base pair has been resubstituted by C:G.", }