RT Journal Article SR Electronic(1) A1 Davison, M.-J. A1 Preston, V. G. A1 McGeoch, D. J.YR 1984 T1 Determination of the Sequence Alteration in the DNA of the Herpes Simplex Virus Type 1 Temperature-sensitive Mutant ts K JF Journal of General Virology, VO 65 IS 5 SP 859 OP 863 DO https://doi.org/10.1099/0022-1317-65-5-859 PB Microbiology Society, SN 1465-2099, AB SUMMARY The alteration in the DNA sequence responsible for the mutant phenotype of the herpes simplex virus type 1 temperature-sensitive mutant ts K has been determined. A single C:G base pair present in the wild-type Vmw 175 immediate-early polypeptide-coding sequence has been replaced by T:A in the mutant gene. This results in the substitution of an alanine by a valine codon. In two revertants the mutant T:A base pair has been resubstituted by C:G., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-65-5-859