1887

Abstract

SUMMARY

Evidence is presented showing that a monkey anti-enterovirus 71 immune serum contains several antibody populations which differ in their mode of function. One population reduces infectivity, although inefficiently, by interactions at exposed antigenic sites and can be detected by measuring residual virus infectivity after mixtures of virus and antibody have been allowed to interact. Another antibody population, which is unaffected by the immunosorbent (Cowan I strain), appears to attach to its antigenic site(s) only after interactions between enterovirus 71 and host cells have already begun. In view of the transience of (presumed) conformational changes in the invading viruses, demonstration of this type of antibody activity requires a particular host cell system. This second type of antibody neutralization could be detected on RD cells but not on green monkey kidney cells.

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/content/journal/jgv/10.1099/0022-1317-66-10-2279
1985-10-01
2024-04-24
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References

  1. Brioen P., Dekegel D., Boeye A. 1983; Neutralization of poliovirus by antibody-mediated polymerization. Virology 127:463–468
    [Google Scholar]
  2. Dulbecco R., Vogt M., Strickland A. G. R. 1956; A study of the basic aspects of neutralization. Two animal viruses, Western equine encephalitis virus and poliomyelitis virus. Virology 2:162–205
    [Google Scholar]
  3. Gunalp A. 1965; Growth and cytopathic effect of rubella virus in a line of green monkey kidney cells. Proceedings of the Society for Experimental Biology and Medicine 118:85–90
    [Google Scholar]
  4. Icenogle J., Shiven H., Duke G., Gilbert S., Rueckert R., Anderegg J. 1983; Neutralization of poliovirus by monoclonal antibody. Virology 127:412–425
    [Google Scholar]
  5. Kjellen L., Schlesinger R. W. 1959; Influence of host cell on residual infectivity of neutralized vesicular stomatitis virus. Virology 7:236–239
    [Google Scholar]
  6. Kjellen L., Von Zeipel G. 1984; Influence of host cells on the infectivity and neutralizability of echovirus type 4 (Pesascek). Intervirology 22:32–40
    [Google Scholar]
  7. Kronvall G., Williams R. C. Jr 1969; Differences in anti-protein A activity among IgG subgroups. Journal of Immunology 103:828–833
    [Google Scholar]
  8. Kronvall G., Simmons A., Myhre E. B., Jonsson S. 1979; Specific absorption of human serum albumin, immunoglobulin A and immunoglobulin G with selected strains of group A and G streptococci. Infection and Immunity 25:1–10
    [Google Scholar]
  9. Lorenz R. J. 1963; Zur Statistik des Plaque-Testes. Archiv fur die gesamte Virusforschung 12:108–137
    [Google Scholar]
  10. McAllister R. M., Melnyk J., Finkelstein J. Z., Adams E. C. Jr, Gardner M. B. 1969; Cultivation in vitro of cells derived from a human rhabdomyosarcoma. Cancer, New York 24:520–526
    [Google Scholar]
  11. Von Zeipel G. 1979; Neutralization of aggregated strains of enterovirus 71 and echovirus type 4 in RD and Vero or GMK-AH1 cells. Acta pathologica et microbiologica scandinavica 87:71–73
    [Google Scholar]
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