Catabolic Sites of Human Interferon-γ Bocci, V. and Pacini, A. and Pessina, G. P. and Paulesu, L. and Muscettola, M. and Lunghetti, G.,, 66, 887-891 (1985), doi = https://doi.org/10.1099/0022-1317-66-4-887, publicationName = Microbiology Society, issn = 0022-1317, abstract= SUMMARY Recombinant human interferon-γ (HuIFN-γ) injected into rabbits disappeared from the circulation more rapidly than natural IFN-γ. The latter displayed an initial decay curve more rapid than that for natural HuIFN-α although 4 h after injection plasma levels were similar. This result suggests that IFN-γ has pharmacokinetic properties different to those of IFN-α which may be explained by considerable and simultaneous hepatic and renal catabolism. Surprisingly, the hepatic uptake of recombinant (unglycosylated) IFN-γ was more marked than uptake of natural IFN-γ. Moreover, both IFN-γ preparations were cleared by the isolated and perfused kidney and once again the recombinant IFN disappeared more rapidly. This result does not conform with the suggestion that IFN-γ exists as a tetramer which would not be filtered by the glomerulus, but is consistent with the pharmacokinetic behaviour shown in vivo., language=, type=