1887

Abstract

Summary

The production of antibody to specific herpes simplex virus type 2 (HSV-2) polypeptides, the recurrence patterns and the susceptibility to re-infection were studied in the guinea-pig model of genital HSV-2 infection. Further, we defined the effects of acyclovir (ACV) therapy on these parameters of infection. Treatment with ACV reduced the clinical severity of the initial disease but did not affect vaginal viral shedding. Production of neutralizing antibody as well as antibody to the nucleocapsid protein, and glycoproteins B, D and G were all delayed in ACV recipients. ACV treatment of initial infection did not significantly alter the pattern of subsequent recurrence although by several criteria treated animals tended towards decreased recurrences. Re-inoculation with a second strain of HSV-2 resulted in a local cervicovaginal infection but, except for one ACV-treated animal, neural tissue was protected from re-infection.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-67-8-1601
1986-08-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/67/8/JV0670081601.html?itemId=/content/journal/jgv/10.1099/0022-1317-67-8-1601&mimeType=html&fmt=ahah

References

  1. Ashley R. L., Corey L. 1984; Effect of acyclovir treatment of primary genital herpes on the antibody response to herpes simplex virus. Journal of Clinical Investigation 73:681–688
    [Google Scholar]
  2. Ashley R., Kern E. 1984; Sequential antibody responses to genital HSV-2 infection in the guinea pig model system. In Program and Abstracts, 24th Interscience Conference on Antimicrobial Agents and Chemotherapy (Washington, D.C.) abstract no. 357
    [Google Scholar]
  3. Bernstein D. I., Lovett M., Bryson Y. J. 1984a; The effects of acyclovir on antibody response to herpes simplex virus in primary genital herpetic infection. Journal of Infectious Diseases 150:7–13
    [Google Scholar]
  4. Bernstein D. I., Lovett M., Bryson Y. J. 1984b; Serologic analysis of first episode non-primary genital HSV infection: presence of HSV-2 antibody in acute sera. American Journal of Medicine 77:1055–1060
    [Google Scholar]
  5. Braun D. K., Pereira L., Norrild B., Roizman B. 1983; Application of denatured, electrophoretically separated and immobilized lysates of herpes simplex virus-infected cells for detection of monoclonal antibodies and for studies of the properties of viral protein. Journal of Virology 46:103–113
    [Google Scholar]
  6. Braun D. K., Roizman B., Pereira L. 1984; Characterization of post-translational products of herpes simplex virus gene 35 protein binding to the surfaces of full capsids but not empty capsids. Journal of Virology 49:142–153
    [Google Scholar]
  7. Bryson Y. J. 1983; Current status and prospects for oral acyclovir treatment of first episode and recurrent genital herpes simplex virus. Journal of Antimicrobial Chemotherapy 12: supplement B 61–69
    [Google Scholar]
  8. Bryson Y. J., Dillon M., Lovett M., Acuna G., Taylor S., Cherry J. D., Johnson B. L., Wiesmeier E., Growdon W., Creagh-kirk T., Keeney R. 1983a; Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. New England Journal of Medicine 308:916–921
    [Google Scholar]
  9. Bryson Y. J., Dillon M., Lovett M., Bernstein D. I., Sayre J. 1983b; A prospective long term study of the natural history of genital HSV infections. In Program and Abstracts, 23rd Interscience Conference on Antimicrobial Agents and Chemotherapy (Las Vegas) abstract no. 739
    [Google Scholar]
  10. Buchman T. G., Roizman B., Adams G., Stover B. H. 1978; Restriction endonuclease fingerprinting of herpes simplex virus DNA: a novel epidemiological tool applied to a nosocomial outbreak. Journal of Infectious Diseases 138:489–498
    [Google Scholar]
  11. Centifanto-Fitzgerald Y. M., Varnell E. D., Kaufman H. E. 1982; Initial herpes simplex virus type 1infection prevents ganglionic superinfection by other strains. Infection and Immunity 35:1125–1132
    [Google Scholar]
  12. Collins P., Appleyard G., Oliver N. M. 1982; Sensitivity of herpes virus isolates from ayclovir clinical trials. American Journal of Medicine 73: supplement 380–382
    [Google Scholar]
  13. Douglas M., Critchlow C., Benedetti J., Mertz G. J. 1984; A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. New England Journal of Medicine 310:1551–1556
    [Google Scholar]
  14. Eberle R., Mou S. W. 1983; Relative titers to individual polypeptide antigens of herpes simplex virus 1 type in human sera. Journal of Infectious Diseases 148:436–444
    [Google Scholar]
  15. Eberle R., Mou S.-W, Zaia J. A. 1984; Polypeptide specificity of the early antibody response following primary and recurrent genital herpes simplex virus type 2 infections. Journal of General Virology 65:1839–1843
    [Google Scholar]
  16. Gilman S. C., Docherty J. J., Rawls W. E. 1981; Antibody response in humans to individual proteins of herpes simplex virus. Infection and Immunity 34:880–887
    [Google Scholar]
  17. KERN E. 1982; Acyclovir treatment of experiment genital herpes simplex virus infection. American Journal of Medicine 73: supplement 100–108
    [Google Scholar]
  18. Kern E. R. 1984; Treatment of genital herpes simplex virus infection in guinea pigs. In Herpes Virus (UCLA Symposia on Molecular and Cellular Biology, New Series Vol. 21) pp 617–636 Edited by Rapp F. New York: Alan R. Liss;
    [Google Scholar]
  19. Klein R. J., Destefano E., Brady E., FiedmaN-kien A. E. 1980; Experimental skin infection with an acyclovir resistant herpes simplex virus mutant: response to antiviral treatment and protection against reinfection. Archives of Virology 65:237–246
    [Google Scholar]
  20. Lonsdale D. M. 1979; A rapid technique for distinguishing herpes simplex virus type 1 from type 2 by restriction- enzyme technology. Lancet i:649–652
    [Google Scholar]
  21. Meignier B., Norrild B., Roizman B. 1983; Colonization of murine ganglia by a superinfecting strain of herpes simplex virus. Infection and Immunity 41:702–708
    [Google Scholar]
  22. Mertz G. J., Critchlow C. W., Benedetti J., Reichman R. C., Dolin R., Connor J., Redfield D. C., Savoia M. C., Richman D. D., Tyrrell D. L., Miedzinski L., Portnoy J., Keeney R. E., Corey L. 1984; Double blind placebo controlled treatment of oral acyclovir in first-episode genital herpes simplex virus infection. Journal of the American Medical Association 252:1147–1151
    [Google Scholar]
  23. Norrild B., Pedersen B., Roizman B. 1981; Immunological reactivity of herpes simplex virus 1 and 2 polypeptides electrophoretically separated and transferred to diazobenzyloxymethyl paper. Infection and Immunity 31:660–667
    [Google Scholar]
  24. Pronovost A. D., Lucia H. L., Dann P. R., Hsiung G. D. 1982; Effect of acyclovir on genital herpes in guinea pigs. Journal of Infectious Diseases 145:904–908
    [Google Scholar]
  25. Quinn R. P., Demiranda P., Gerald L., Good S. S. 1979; A sensitive radioimmunoassay for the antiviral agent BW 248U [9-(2-hydroxyethoxymethyl)guanine]. Annals of Biochemistry 98:319–328
    [Google Scholar]
  26. Schmidt O. W., Fife K. H., Corey L. 1984; Reinfection is an uncommon occurrence in patients with symptomatic recurrent genital herpes. Journal of Infectious Diseases 145:645–646
    [Google Scholar]
  27. Stanberry L. R., Kern E. R., Richards J. T., ABBOTT T. M., Overall J. C. JR 1982; Genital herpes in guinea pigs: pathogenesis of the primary infection and description of recurrent disease. Journal of Infectious Diseases 146:391–404
    [Google Scholar]
  28. Stanberry L. R., Kit S., Myers M. G. 1985; Thymidine kinase-deficient herpes simplex virus type 2 genital infection in guinea pigs. Journal of Virology 55:322–328
    [Google Scholar]
  29. Stanberry L. R., Bernstein D. I., Kit S., Myers M. G. 1986; Genital reinfection after recovery from initial herpes simplex virus type 2 genital infection in guinea pigs. Journal of Infectious Diseases (in press)
    [Google Scholar]
  30. Straus S. E., Tariff H. E., Seidlin M., Bachrach S., Lininger L. D., Di Giovanna J. J., Western K. A., Smith H. A., Nusinoff Lehrman S., Creagh-kirk T., Alling D. W. 1984; Suppression of frequently recurring genital herpes. A placebo-controlled double blind trial of oral acyclovir. New England Journal ofMedicine 310:1545–1550
    [Google Scholar]
  31. Zweerink H. J., Corey L. 1982; Virus specific antibodies from patients with genital herpes simplex virus infection. Infection and Immunity 37:413–420
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-67-8-1601
Loading
/content/journal/jgv/10.1099/0022-1317-67-8-1601
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error