f Purified Influenza Virus Nucleoprotein Protects Mice from Lethal Infection
- Authors: David C. Wraith, Angela E. Vessey, Brigitte A. Askonas
- First Published Online: 01 February 1987, Journal of General Virology 68: 433-440, doi: 10.1099/0022-1317-68-2-433
- Subject: Animal
- Issue Published:
Local administration of nucleoprotein purified from X31 (H3N2) influenza A virus primed for A virus cross-reactive cytotoxic T cells and resulted in substantial protection (75%) of mice from a lethal challenge with the heterologous mouse-adapted A/PR/8/34 (H1N1) virus. By following the course of a lethal virus challenge we found that nucleoprotein priming did not prevent virus infection but rather aided recovery. Nucleoprotein-primed mice suffered initial symptoms of infection, i.e. weight loss and surface temperature changes, but started to recover after approximately 7 days. We suggest that such heterotypic protection can be attributed to priming of A virus cross-reactive cytotoxic T cells.
© Society for General Microbiology 1987 | Published by the Microbiology Society
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