RT Journal Article SR Electronic(1) A1 Wraith, David C. A1 Vessey, Angela E. A1 Askonas, Brigitte A.YR 1987 T1 Purified Influenza Virus Nucleoprotein Protects Mice from Lethal Infection JF Journal of General Virology, VO 68 IS 2 SP 433 OP 440 DO https://doi.org/10.1099/0022-1317-68-2-433 PB Microbiology Society, SN 1465-2099, AB SUMMARY Local administration of nucleoprotein purified from X31 (H3N2) influenza A virus primed for A virus cross-reactive cytotoxic T cells and resulted in substantial protection (75 %) of mice from a lethal challenge with the heterologous mouse-adapted A/PR/8/34 (H1N1) virus. By following the course of a lethal virus challenge we found that nucleoprotein priming did not prevent virus infection but rather aided recovery. Nucleoprotein-primed mice suffered initial symptoms of infection, i.e. weight loss and surface temperature changes, but started to recover after approximately 7 days. We suggest that such heterotypic protection can be attributed to priming of A virus crossreactive cytotoxic T cells., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-68-2-433