f Inhibition of BK Virus Haemagglutination by Gangliosides
- Authors: Laura Sinibaldi, Donatella Viti, Paola Goldoni, Giovanni Cavallo, Cecilia Caroni, Nicola Orsi
- First Published Online: 01 March 1987, Journal of General Virology 68: 879-883, doi: 10.1099/0022-1317-68-3-879
- Subject: Animal
- Issue Published:
The effect of gangliosides extracted from human group O Rh+ erythrocytes on haemagglutination by BK virus was investigated. Experiments were performed on both ganglioside mixtures and isolated fractions separated by column chromatography and characterized by thin-layer chromatography. These results were compared with those obtained with standard preparations of gangliosides, and the inhibiting activity was shown to be confined mainly to gangliosides with a RF lower than GM1. It was also observed that the insertion of gangliosides in liposomes increased the haemagglutination-inhibiting activity and that ganglioside coating restored the ability of glycosidase-treated human red blood cells to agglutinate.
© Society for General Microbiology 1987 | Published by the Microbiology Society
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