RT Journal Article SR Electronic(1) A1 Morrow, W. J. W. A1 Wharton, M. A1 Lau, D. A1 Levy, J. A.YR 1987 T1 Small Animals Are Not Susceptible to Human Immunodeficiency Virus Infection JF Journal of General Virology, VO 68 IS 8 SP 2253 OP 2257 DO https://doi.org/10.1099/0022-1317-68-8-2253 PB Microbiology Society, SN 1465-2099, AB Summary Several species of small animals were inoculated at birth or as adults with blood components from patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related disorders, or with the human immunodeficiency virus (HIV). No ill effects were noted in rats, hamsters, guinea-pigs, rabbits or musk shrews. Mice inoculated with clinical specimens had a significant incidence of mortality as compared with control groups (18·7% against 5·9%, P < 0·025). Mice receiving HIV showed an increase in mortality, but it was not statistically significant. Infection of the animals by HIV could not be detected by virological or immunological studies. We concluded that none of these animal species provided a useful model for evaluating HIV infection., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-68-8-2253