f The Fusion Glycoproteins of Human Respiratory Syncytial Virus of Subgroups A and B: Sequence Conservation Provides a Structural Basis for Antigenic Relatedness
- Authors: Philip R. Johnson, Peter L. Collins
- J. Gen. Virol., October 1988 69: 2623-2628, doi: 10.1099/0022-1317-69-10-2623
- Subject: Animal
- Published Online:
Two major antigenic subgroups (A and B) have been described for human respiratory syncytial virus. The complete nucleotide sequence was determined for the fusion (F) mRNA of the subgroup B strain 18537 and the amino acid sequence of the F protein deduced, for comparison with the previously described sequences for the A2 strain of subgroup A. The F proteins (excluding the cleaved signal peptide) were 91% identical between the subgroups, consistent with the previously described high degree of antigenic relatedness. The greatest divergence occurred within the F2 subunit immediately preceding the cleavage activation site.
© Society for General Microbiology 1988 | Published by the Microbiology Society
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/content/journal/jgv/10.1099/0022-1317-69-10-2623dcterms_title,dcterms_subject-pub_serialIdent:journal/jgv AND -contentType:BlogPost64
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