%0 Journal Article %A Johnson, Philip R. %A Collins, Peter L. %T The Fusion Glycoproteins of Human Respiratory Syncytial Virus of Subgroups A and B: Sequence Conservation Provides a Structural Basis for Antigenic Relatedness %D 1988 %J Journal of General Virology, %V 69 %N 10 %P 2623-2628 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-69-10-2623 %K human %K sequence conservation %K fusion glycoproteins %K RSV %I Microbiology Society, %X Summary Two major antigenic subgroups (A and B) have been described for human respiratory syncytial virus. The complete nucleotide sequence was determined for the fusion (F) mRNA of the subgroup B strain 18537 and the amino acid sequence of the F protein deduced, for comparison with the previously described sequences for the A2 strain of subgroup A. The F proteins (excluding the cleaved signal peptide) were 91% identical between the subgroups, consistent with the previously described high degree of antigenic relatedness. The greatest divergence occurred within the F2 subunit immediately preceding the cleavage activation site. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-69-10-2623