1887

Abstract

Summary

The development of autoimmunity was investigated in BALB/c and C58 mice infected with lactate dehydrogenase-elevating virus (LDV). Autoantibodies reactive by ELISA with syngeneic central nervous system antigens appeared early during LDV infection of both strains of mice, and were maintained for many months. Western blot analysis indicated that the LDV-induced autoantibodies reacted with a variety of different brain antigens, and mouse strain differences in the pattern of autoreactivity were observed. LDV infection of C58 and BALB/c mice also stimulated antibodies reactive with syngeneic liver-, kidney- and spleen-derived antigens, and in Swiss outbred mice heart-reactive antibodies were observed following LDV infection. These results show that autoimmunity is a feature of the deregulation of the immune system which occurs during LDV infection.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-69-3-723
1988-03-01
2024-04-19
Loading full text...

Full text loading...

/deliver/fulltext/jgv/69/3/JV0690030723.html?itemId=/content/journal/jgv/10.1099/0022-1317-69-3-723&mimeType=html&fmt=ahah

References

  1. AHMED R., OLDSTONE M. B. A. 1984 Mechanisms and biological implications of virus-induced polyclonal B-cell activation. Concepts in Viral Pathogenesis231–238 Edited by Notkins A. L., Oldstone M. B. A. Vienna & New York: Springer-Verlag;
    [Google Scholar]
  2. BUTCHKO G., ARMSTRONG R., MARTIN W., ENNIS F. A. 1978; Influenza A viruses of the N2N2 subtype are lymphocyte mitogens. Nature, London 271:66–67
    [Google Scholar]
  3. CAFRUNY W. A., PLAGEMANN P. G. W. 1982a; Immune response to lactate dehydrogenase-elevating virus: isolation of infectious virus-immunoglobulin G complexes and quantitation of specific antiviral immunoglobulin G response in wild-type and nude mice. Infection and Immunity 37:1001–1006
    [Google Scholar]
  4. CAFRUNY W. A., PLAGEMANN P. G. W. 1982b; Immune response to lactate dehydrogenase-elevating virus: serologically specific rabbit neutralizing antibody to the virus. Infection and Immunity 37:1007–1012
    [Google Scholar]
  5. CAFRUNY W. A., STRANCKE C. R., KOWALCHYK K., PLAGEMANN P. G. W. 1986a; Replication of lactate dehydrogenase-elevating virus in C58 mice and quantification of antiviral antibodies and of tissue virus levels as a function of development of paralytic disease. Journal of General Virology 67:27–37
    [Google Scholar]
  6. CAFRUNY W. A., HERUTH D., JAQUA M. J., PLAGEMANN P. G. W. 1986b; Immunoglobulins that bind to uncoated ELISA plate surfaces: appearance in mice during infection with lactate-dehydrogenase elevating virus and in human anti-nuclear antibody-positive sera. Journal of Medical Virology 19:175–186
    [Google Scholar]
  7. CAFRUNY W. A., CHAN S. P. K., HARTY J. T., YOUSEFI S., KOWALCHYK K., McDONALD D., FOREMAN B., BUDWEG G., PLAGEMANN P. G. W. 1986c; Antibody response of mice to lactate dehydrogenase-elevating virus during infection and immunization with inactivated virus. Virus Research 5:357–375
    [Google Scholar]
  8. COUTELIER J.-P., VAN SNICK J. 1985; Isotypically restricted activation of B-1ymphocytes by lactic dehydrogenase virus. European Journal of Immunology IS:250–255
    [Google Scholar]
  9. DRESSER D. W. 1978; Most Igm-producing cells in the mouse secrete auto-antibodies (rheumatoid factor). Nature, London 274:480–483
    [Google Scholar]
  10. FUJINAMI R. S., OLDSTONE M. B. A. 1985; Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science 230:1043–1045
    [Google Scholar]
  11. FUJINAMI R. S., OLDSTONE M. B. A., WROBLEWSKA Z., FRANKEL M. E., KOPROWSKI H. 1983; Molecular mimicry in virus infection: cross-reaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments. Proceedings of the National Academy of Sciences, U.S.A 80:2346–2350
    [Google Scholar]
  12. GARZELLI C. F., TAUB R. E., SCHARFF J. E., PRABHAKAR B. S., GINSBERG-FELLNER F., NOTKINS A. L. 1984; Epstein-Barr virus-transformed lymphocytes produce monoclonal autoantibodies that react with antigens in multiple organs. Journal of Virology 52:722–725
    [Google Scholar]
  13. GIBSON M., TIENSIWAKUL P., KHOOBYARIAN N. 1982; Adenovirus fiber protein (FP) functions as a mitogen and an adjuvant. Cellular Immunology 73:397–403
    [Google Scholar]
  14. HANG L., SLACK J. H., AMUNDSON C, IZUI S., THEOFILOPOULOS A. N., DIXON F. J. 1983; Induction of murine autoimmune disease by chronic polyclonal B-cell activation. Journal of Experimental Medicine 157:874–883
    [Google Scholar]
  15. HIRSCH M. S., PROFFITT M. R. 1975 Autoimmunity in viral infection. Viral Immunology and Immunopathology419–434 Edited by Notkins A. L. New York: Academic Press;
    [Google Scholar]
  16. HUTT-FLETCHER L., BALACHANDRAN N., ELKINS M. 1983; B-cell activation by cytomegalovirus. Journal of Experimental Medicine 158:2171–2176
    [Google Scholar]
  17. MARTINEZ D., BRINTON M. A., TACHOVSKY T. G., PHELPS A. H. 1980; Identification of lactate dehydrogenase-elevating virus as the etiologic agent of the genetically restricted age-dependent polioencephalitis of mice. Infection and Immunity 27:979–987
    [Google Scholar]
  18. MOCHIZUKI D., HEDRICK S., WATSON J., KINGSBURY D. 1977; The interaction of herpes simplex virus with murine lymphocytes. I. Mitogenic properties of herpes simplex virus. Journal of Experimental Medicine 146:1500–1510
    [Google Scholar]
  19. MURPHY W. H., NAWROCKI J. F., PEASE L. F. 1983; Age-dependent paralytic viral infection in C58 mice: possible implications in human neurological disease. Progress in Brain Research 59:291–303
    [Google Scholar]
  20. NAWROCKI J. F., PEASE L., MURPHY W. H. 1980; Etiologic role of lactate-dehydrogenase virus infections in an age-dependent neuroparalytic disease in C58 mice. Virology 103:259–264
    [Google Scholar]
  21. NOTKINS A. L., MAGE M., ASHE W. K., MAHAR S. 1968; Neutralization of sensitized lactic dehydrogenase virus by antiglobulin. Journal of Immunology 100:314–320
    [Google Scholar]
  22. NOTKINS A. L., ONODERA T., PRABHAKAR B. 1984 Virus-induced autoimmunity. Concepts in Viral Pathogenesis210–215 Edited by Notkins A. L., Oldstone M. B. A. Vienna & New York: Springer-Verlag;
    [Google Scholar]
  23. ROSEN A., GERGELY P., JONDAL M., KLEIN G. 1977; Polyclonal Ig production after Epstein-Barr virus infection of human lymphocytes in vitro. Nature, London 267:52–53
    [Google Scholar]
  24. ROWSON K. E. K., MAHY B. W. J. 1975 Lactic dehydrogenase virus. Virology Monographs 13 Vienna & New York: Springer-Verlag;
    [Google Scholar]
  25. STEELE E. J., CUNNINGHAM A. I. 1978; High proportion of Ig-producing cells making autoantibody in normal mice. Nature, London 274:483–484
    [Google Scholar]
  26. STROOP W. G., BRINTON M. A. 1985; Enhancement of encephalomyeloradiculitis in mice sensitized with spinal cord tissue and infected with lactate dehydrogenase-elevating virus. Journal of Neuroimmunology 8:79–92
    [Google Scholar]
  27. WEILAND E., WEILAND F., GROSSMANN A. 1987; Lactate dehydrogenase-elevating virus induces anti-Golgi apparatus antibodies. Journal of General Virology 68:1983–1991
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-69-3-723
Loading
/content/journal/jgv/10.1099/0022-1317-69-3-723
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error