Replication of the Scrapie Agent in Hamsters Infected Intracerebrally Confirms the Pathogenesis of an Amyloid-inducing Virosis

References

1. BARINGER J. R., BOWMAN K. A., PRUSINER S. B. 1983; Replication of scrapie agent in hamster brain precedes neuronal vacuolation. Journal of Neuropathology and Experimental Neurology 42:539–547
   [Google Scholar]
2. BENDHEIM P. E., BOLTON D. C. 1986; A 54-kDa normal cellular protein may be the precursor of the scrapie agent protease-resistant protein. Proceedings of the National Academy of Sciences, U.S.A 83:2214–2218
   [Google Scholar]
3. BRAIG H. R., DIRINGER H. 1985; Scrapie: concept of a virus-induced amyloidosis of the brain. EMBO Journal 4:2309–2312
   [Google Scholar]
4. CHESEBRO B., RACE R., WEHRLY K., NISHIO J., BLOOM M., LECHNER D., BERGSTROM S., ROBBINS K., MAYER L., KEITH J. M., GARON C., HAASE A. 1985; Identification of scrapie prion protein-specific mRNA in scrapie-infected brain. Nature, London 315:331–333
   [Google Scholar]
5. CZUB M., BRAIG H. R., BLODE H., DIRINGER H. 1986a; The major protein of SAF is absent from spleen and thus not an essential part of the scrapie agent. Archives of Virology 91:383–386
   [Google Scholar]
6. CZUB M., BRAIG H. R., DIRINGER H. 1986b; Pathogenesis of scrapie: study of the temporal development of clinical symptoms, of infectivity titres and scrapie-associated fibrils in brains of hamsters infected intraperitoneally. Journal of General Virology 67:2005–2009
   [Google Scholar]
7. DIRINGER H. 1984; Sustained viremia in experimental hamster scrapie. Archives of Virology 82:105–109
   [Google Scholar]
8. DIRINGER H., GELDERBLOM H., HILMERT H., ÖZEL M., EDELBLUTH C., KIMBERLIN R. H. 1983; Scrapie infectivity, fibrils and low molecular weight protein. Nature, London 306:476–478
   [Google Scholar]
9. DIRINGER H., BRAIG H. R., POCCHIARI M., BODE L. 1986; Scrapie-associated fibrils in the pathogenesis of diseases caused by unconventional slow viruses. Discussions in Neurosciences 3:95–100145–157
   [Google Scholar]
10. FENNER F., BACHMANN P. A., GIBBS E. P. J., MURPHY F. A., STUDDERT M. J., WHITE D. O. 1987 Mechanisms of persistent infections; subacute spongiform encephalopathies. Veterinary Virology203–216609–614 Orlando & London: Academic Press;
    [Google Scholar]
11. GAJDUSEK D. C. 1985 Unconventional viruses causing subacute spongiform encephalopathies. Virology1519–1557 Edited by Fields B. N., Knipe D. M., Chanock R. M., Melnick J. L., Roizman B., Shope R. E. New York: Raven Press;
    [Google Scholar]
12. HOGAN R. N., BOWMAN K. A., BARINGER J. R., PRUSINER S. B. 1986; Replication of scrapie prions in hamster eyes precedes retinal degeneration. Ophthalmic Research 18:230–235
    [Google Scholar]
13. KIMBERLIN R. H. 1976; Experimental scrapie in the mouse: a review of an important model disease. Science Progress 63:461–481
    [Google Scholar]
14. KIMBERLIN R. H., WALKER C. A. 1977; Characteristics of a short incubation model of scrapie in the golden hamster. Journal of General Virology 34:295–304
    [Google Scholar]
15. KIMBERLIN R. H., WALKER C. A. 1986; Pathogenesis of scrapie (strain 263K) in hamsters infected intracerebrally, intraperitoneally or intraocularly. Journal of General Virology 67:255–263
    [Google Scholar]
16. MERZ P. A., SOMERVILLE R. A., WISNIEWSKI H. M., IQBAL K. 1981; Abnormal fibrils from scrapie-infected brain. Acta neuropathologica 54:63–74
    [Google Scholar]
17. MERZ P. A., KASCSAK R. J., RUBENSTEIN R., CARP R. I., WISNIEWSKI H. M. 1987; Antisera to scrapie-associated fibril protein and prion protein decorate scrapie-associated fibrils. Journal of Virology 61:42–49
    [Google Scholar]
18. MOREAU-DUBOIS M.-C., BROWN P., ROHWER R. G., MASTERS C. L., FRANKO M., GAJDUSEK D. C. 1982; Experimental scrapie in golden Syrian hamsters: temporal comparison of in vitro cell-fusing activity with brain infectivity and histopathological changes. Infection and Immunity 37:195–199
    [Google Scholar]
19. OESCH B., WESTAWAY D., WÄLCHLI M., MCKINLEY M. P., KENT S. B. H., AEBERSOLD K., BARRY R. A., TEMPST P., TEPLOW D. B., HOOD L. E., PRUSINER S. B., WEISSMANN C. 1985; A cellular gene encodes scrapie PrP 27-30 protein. Cell 40:735–746
    [Google Scholar]
20. PRUSINER S. B. 1982; Novel proteinaceous infectious particles cause scrapie. Science 216:136–144
    [Google Scholar]
21. PRUSINER S. B., MCKINLEY M. P., BOWMAN K. A., BOLTON D. C, BENDHEIM P. E., GROTH D. F., GLENNER G. G. 1983; Scrapie prions aggregate to form amyloid-like birefringent rods. Cell 35:349–358
    [Google Scholar]