Characterization of a New Temperature-sensitive and Avirulent Mutant of the Rabies Virus
Préhaud, C. and Coulon, P. and Diallo, A. and Martinet-Edelist, C. and Flamand, A.,, 70, 133-143 (1989),
doi = https://doi.org/10.1099/0022-1317-70-1-133,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= SUMMARY A temperature-sensitive (ts) mutant, tsG1, has been isolated from the CVS (Challenge Virus Standard) strain of rabies virus. The ts mutation affects the glycoprotein (G protein); it consists of an amino acid substitution (leucine to phenylalanine) at position 132. tsG1 exhibits a slightly reduced pathogenicity when administered via the intracerebral route and complete avirulence after intramuscular inoculation, associated with a very high protective power for adult mice. The ts mutation does not seem to block the transport of the G protein to the plasma membrane at the non-permissive temperature (39.6 °C). It abolishes the c.p.e. of the virus in cell cultures.,
language=,
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