RT Journal Article SR Electronic(1) A1 Van Campen, Hana A1 Easterday, Bernard C. A1 Hinshaw, Virginia S.YR 1989 T1 Destruction of Lymphocytes by a Virulent Avian Influenza A Virus JF Journal of General Virology, VO 70 IS 2 SP 467 OP 472 DO https://doi.org/10.1099/0022-1317-70-2-467 PB Microbiology Society, SN 1465-2099, AB SUMMARY Infection of chickens by a virulent avian influenza A virus, A/turkey/Ont/7732/66 (H5N9), was associated with a severe lymphopenia. High titres of infectious virus were found in lymphoid tissues early in infection and were accompanied by severe damage to the lymphocyte populations as demonstrated by histopathological examination. Non-lymphoid cell populations in these tissues were unaffected, as were other organs examined. The viral nucleoprotein was localized by immunoperoxidase staining to lymphocytes in affected tissues early in infection., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-70-2-467