1887

Abstract

SUMMARY

Neonatal ferrets are protected against infection with influenza virus by milk-derived anti-influenza virus IgG after suckling on an immune mother. Live vaccines protect better than killed vaccines despite their stimulation of lower maternal haemagglutination-inhibiting antibody levels. This suggests that antibody to virus proteins other than the haemagglutinin may also be involved. To investigate this, adult ferrets were immunized intradermally with live vaccinia-influenza virus recombinants each expressing one of the 10 influenza virus polypeptides. Adult ferrets immunized with a recombinant expressing the H3 haemagglutinin were completely protected, and also passively protected their offspring, against a live challenge with clone 7a of the reassortant influenza virus A/Puerto Rico/8/34–A/England/939/69 (H3N2), immunity being mediated by IgG antibody. However, ferrets immunized similarly with recombinants expressing the H1 haemagglutinin, neuraminidase (N1 or N2), polymerases (PB1, PB2 or PAC), matrix protein (M1 or M2), nucleoprotein (NP) or non-structural proteins (NS1 or NS2) were completely susceptible to the influenza virus.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-70-6-1523
1989-06-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/70/6/JV0700061523.html?itemId=/content/journal/jgv/10.1099/0022-1317-70-6-1523&mimeType=html&fmt=ahah

References

  1. Ada G. L., Jones P. D. 1986; The immune response to influenza infection.. Current Topics in Microbiology and Immunology 128:1–54
    [Google Scholar]
  2. Ada G. L., Mak N. K., Sweet C. 1983; The regulation of influenza virus infection.. Progress in Immunology 5:1295–1304
    [Google Scholar]
  3. Andrew M. E., Coupar B. E. H., Boyle D. B., Ada G. L. 1987; The roles of influenza virus haemagglutinin and nucleoprotein in protection : analysis using vaccinia virus recombinants.. Scandinavian Journal of Immunology 25:21–28
    [Google Scholar]
  4. Askonas B. A., Mcmichael A. J., Webster R. G. 1982; The immune response to influenza viruses and the problem of protection against infection.. In Basic and Applied Influenza Research159–188 Beare A. S. Boca Raton: CRC Press;
    [Google Scholar]
  5. Balkovic E. S., Florack J. A., Six H. R. 1987; Immunoglobulin G subclass antibody responses of mice to influenza virus antigens given in different forms.. Antiviral Research 8:151–160
    [Google Scholar]
  6. Basarab O., Smith H. 1969; Quantitative studies on the tissue localization of influenza virus in ferrets after intranasal and intravenous or intracardial inoculation.. British Journal of Experimental Pathology 50:612–618
    [Google Scholar]
  7. Bastin J. M., Townsend A. R. M., McMichael A. J. 1987; Specific recognition of influenza virus polymerase protein (PB1) by a murine cytotoxic T-cell clone.. Virology 160:278–280
    [Google Scholar]
  8. Becht H., Gruschkau H., Rott R. 1979; The M protein of influenza viruses has no immunizing effect.. Medical Microbiology and Immunology 167:285–288
    [Google Scholar]
  9. Bennink J. R., Yewdell J. W., Smith G. L., Moss B. 1987; Anti-influenza virus cytotoxic T lymphocytes recognize the three viral polymerases and a non-structural protein: responsiveness to individual antigens is major histocompatibility complex controlled.. Journal of Virology 61:1098–1102
    [Google Scholar]
  10. Boyle D. B., Coupar B. E. H., Parsonson I. M., Bagust T. J., Both G. W. 1986; Responses of cattle, sheep and poultry to a recombinant vaccinia virus expressing a swine influenza haemagglutinin.. Research in Veterinary Science 41:40–44
    [Google Scholar]
  11. Buller R. M. L., Smith G. L., Cremer K., Notkins A. L., Moss B. 1985; Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype.. Nature, London 317:813–815
    [Google Scholar]
  12. Coates D. M., Husseini R. H., Collie M. H., Sweet C., Smith H. 1984; The role of cellular susceptibility in the declining severity of respiratory influenza of ferrets with age.. British Journal of Experimental Pathology 65:29–39
    [Google Scholar]
  13. Coates D. M., Sweet C., Smith H. 1986; Severity of fever in influenza: differential pyrogenicity in ferrets exhibited by H1N1 and H3N2 strains of differing virulence.. Journal of General Virology 67:419–425
    [Google Scholar]
  14. Coupar B. E. H., Andrew M. E., Both G. C., Boyle D. B. 1986; Temporal regulation of influenza haemagglutinin expression in vaccinia virus recombinants and effects on the immune response.. European Journal of Immunology 16:1479–1487
    [Google Scholar]
  15. Coutelier J. P., Van Der Logt J. T. M., Heessen F. W. A., Warnier G., Van Snick J. 1987; IgG2a restriction of murine antibodies elicited by viral infections.. Journal of Experimental Medicine 165:64–69
    [Google Scholar]
  16. Cretescu L., Beare A. S., Schild G. C. 1978; Formation of antibody to matrix protein in experimental human influenza A virus infections.. Infection and Immunity 22:322–327
    [Google Scholar]
  17. Dimmock N. J. 1987; Multiple mechanisms of neutralization of animal viruses.. Trends in Biochemical Sciences 12:70–75
    [Google Scholar]
  18. Gotch F., McMichael A., Smith G. L., Moss B. 1987; Identification of viral molecules recognised by influenzaspecific human cytotoxic T lymphocytes.. Journal of Experimental Medicine 165:408–416
    [Google Scholar]
  19. Gould E. A., Ratcliffe N. A., Basarab O., Smith H. 1972; Studies on the basis of localization of influenza virus in ferret organ cultures.. British Journal of Experimental Pathology 53:31–36
    [Google Scholar]
  20. Hocart M. J., Mackenzie J. S., Stewart G. A. 1988; The IgG subclass responses induced by wild-type, cold-adapted and purified haemagglutinin from influenza virus A/Queensland/6/72 in CBA/CaH mice.. Journal of General Virology 69:1873–1882
    [Google Scholar]
  21. Husseini R. H., Collie M. H., Rushton D. I., Sweet C., Smith H. 1983; The role of naturally-acquired bacterial infection in influenza-related death in neonatal ferrets.. British Journal of Experimental Pathology 64:559–569
    [Google Scholar]
  22. Husseini R. H., Sweet C., Overton H. A., Smith H. 1984; Role of maternal immunity in the protection of newborn ferrets against infection with a virulent influenza virus.. Immunology 52:389–394
    [Google Scholar]
  23. Mackett M., Smith G. L. 1986; Vaccinia virus expression vectors.. Journal of General Virology 67:2067–2082
    [Google Scholar]
  24. Mackett M., Yilma T., Rose J. K., Moss B. 1985; Vaccinia virus recombinants: expression of VSV genes and protective immunization of mice and cattle.. Science 227:433–435
    [Google Scholar]
  25. McLaren C., Butchko G. M. 1978; Regional T- and B-cell responses in influenza-infected ferrets.. Infection and Immunity 22:189–194
    [Google Scholar]
  26. Matsuyama T., Sweet C., Collie M. H., Smith H. 1980; Aspects of virulence in ferrets exhibited by influenza virus recombinants of known genetic constitution.. Journal of Infectious Diseases 141:351–361
    [Google Scholar]
  27. Murphy B. R., Prince G. A., Walsh E. E., Parrott R. H., Hemming V. G., Rodriguez W. J., Chanock R. M. 1986; Dissociation between serum neutralizing and glycoprotein antibody responses of infants and children who received inactivated respiratory syncytial virus vaccine.. Journal of Clinical Microbiology 24:197–202
    [Google Scholar]
  28. Oxford J. S., Schild G. C. 1976; Immunological and physicochemical studies of influenza matrix (M) polypeptides.. Virology 74:394–402
    [Google Scholar]
  29. Perkus M. E., Piccini A., Lipinskas B. R., Paoletti E. 1985; Recombinant vaccinia virus: immunization against multiple pathogens.. Science 229:981–984
    [Google Scholar]
  30. Potter C. W. 1982; Inactivated influenza virus vaccine.. In Basic and Applied Influenza Research119–158 Beare A. S. Boca Raton: CRC Press;
    [Google Scholar]
  31. Potter C. W., Oxford J. S., Shore S. L., McLaren C., Stuart-Harris C. 1972a; Immunity to influenza in ferrets. I. Response to live and killed virus.. British Journal of Experimental Pathology 53:153–167
    [Google Scholar]
  32. Potter C. W., Shore S. L., McLaren C., Stuart-Harris C. 1972b; Immunity to influenza in ferrets. II. Influence of adjuvants on immunization.. British Journal of Experimental Pathology 53:168–179
    [Google Scholar]
  33. Rota P. A., Shaw M. W., Kendal A. P. 1987; Comparison of the immune response to variant influenza type B hemagglutinins expressed in vaccinia virus.. Virology 161:269–275
    [Google Scholar]
  34. Schulman J. L., Khakpour M., Kilbourne E. D. 1968; Protective effects of specific immunity to viral neuraminidase on influenza virus infection of mice.. Journal of Virology 2:778–786
    [Google Scholar]
  35. Shore S. L., Potter C. W., McLaren C. 1972; Immunity to influenza in ferrets. IV. Antibody in nasal secretions.. Journal of Infectious Diseases 126:394–400
    [Google Scholar]
  36. Small P. A., Smith G. L., Moss B. 1985; Intranasal vaccination with a recombinant vaccinia virus containing influenza hemagglutinin prevents both influenza virus pneumonia and nasal infection: intradermal vaccination prevents only viral pneumonia.. In Vaccines ’85 : Molecular and Chemical Basis of Resistance to Parasitic, Bacterial and Viral Diseases175–176 Lerner R. A., Chanock R. M., Brown F. New York: Cold Spring Harbor Laboratory;
    [Google Scholar]
  37. Smith G. L., Murphy B. R., Moss B. 1983; Construction and characterization of an infectious vaccinia recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters.. Proceedings of the National Academy of Sciences, U.S.A. 80:7155–7159
    [Google Scholar]
  38. Smith G. L., Levin J. Z., Palese P., Moss B. 1987; Synthesis and cellular location of the ten influenza polypeptides individually expressed by recombinant vaccinia viruses.. Virology 160:336–345
    [Google Scholar]
  39. Smith H., Sweet C. 1988; Lessons for human influenza from pathogenicity studies with ferrets.. Review of Infectious Diseases 10:56–75
    [Google Scholar]
  40. Spiegelberg H. L. 1974; Biological activities of immunoglobulins of different classes and subclasses.. Advances in Immunology 19:259–294
    [Google Scholar]
  41. Sweet C., Stephen J., Smith H. 1974a; Purification of influenza viruses using disulphide-linked immunosorbents derived from rabbit antibody.. Immunochemistry 11:295–304
    [Google Scholar]
  42. Sweet C., Stephen J., Smith H. 1974b; The behaviour of antigenically related influenza viruses of differing virulence on disulphide-linked immunosorbents.. Immunochemistry 11:823–826
    [Google Scholar]
  43. Sweet C., Stephen J., Smith H. 1974c; Immunization of ferrets against influenza: a comparison of killed ferret grown and egg grown virus.. British Journal of Experimental Pathology 55:296–304
    [Google Scholar]
  44. Sweet C., Toms G. L., Smith H. 1977; The pregnant ferret as a model for studying the congenital effects of influenza virus infection in utero : infection of foetal tissues in organ culture and in vivo. British Journal of Experimental Pathology 58:113–123
    [Google Scholar]
  45. Sweet C., Macartney J. C., Bird R. A., Cavanagh D., Collie M. H., Husseini R. H., Smith H. 1981; Differential distribution of virus and histological damage in the lower respiratory tract of ferrets infected with influenza viruses of differing virulence.. Journal of General Virology 54:103–114
    [Google Scholar]
  46. Sweet C., Bird R. A., Jakeman K. J., Coates D. M., Smith H. 1987a; Production of passive immunity in neonatal ferrets following maternal vaccination with killed influenza A virus vaccines.. Immunology 60:83–89
    [Google Scholar]
  47. Sweet C., Jakeman K. J., Smith H. 1987b; Role of milk-derived IgG in passive maternal protection of neonatal ferrets against influenza.. Journal of General Virology 68:2681–2686
    [Google Scholar]
  48. Taylor H. P., Dimmock N. J. 1985a; Mechanisms of neutralization of influenza virus by IgM.. Journal of General Virology 66:903–907
    [Google Scholar]
  49. Taylor H. P., Dimmock N. J. 1985b; Mechanism of neutralization of influenza by secretory IgA is different from that of monomeric IgA or IgG.. Journal of Experimental Medicine 161:198–209
    [Google Scholar]
  50. Taylor P. M., Askonas B. A. 1986; Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo. Immunology 58:417–420
    [Google Scholar]
  51. Toms G. L., Bird R. A., Kingsman S. M., Sweet C., Smith H. 1976; The behaviour in ferrets of two closely related clones of influenza virus of differing virulence for man.. British Journal of Experimental Pathology 57:37–48
    [Google Scholar]
  52. Toms G. L., Davies J. A., Woodward C. G., Sweet C., Smith H. 1977; The relation of pyrexia and nasal inflammatory response to virus levels in nasal washings of ferrets infected with influenza viruses of differing virulence.. British Journal of Experimental Pathology 58:444–458
    [Google Scholar]
  53. Virelizier J. L., Allison A. C., Schild G. C. 1979; Immune responses to influenza virus in the mouse and their role in control of infection.. British Medical Bulletin 35:65–68
    [Google Scholar]
  54. Webster R. G., Reay P. A., Laver W. G. 1988; Protection against lethal influenza with neuraminidase.. Virology 164:230–237
    [Google Scholar]
  55. Wysocka M., Bennink J. R. 1988; Limiting dilution analysis of memory cytotoxic T lymphocytes specific for individual virus gene products.. Cellular Immunology 112:425–429
    [Google Scholar]
  56. Yewdell J. W., Bennink J. R., Smith G. L., Moss B. 1985; Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes.. Proceedings of the National Academy of Sciences, U.S.A. 82:1785–1789
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-70-6-1523
Loading
/content/journal/jgv/10.1099/0022-1317-70-6-1523
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error