f Molecular biology of the Bunyaviridae
- By Richard M. Elliott
- First Published Online: 01 March 1990, Journal of General Virology 71: 501-522, doi: 10.1099/0022-1317-71-3-501
- Subject: Review Article
- Issue Published:
Introduction. More than 300 viruses, mostly arthropod-transmitted, are classified into the family Bunyaviridae, making it one of the largest groupings of animal viruses (Karabatsos, 1985). Until relatively recently these viruses were somewhat the ‘Cinderellas’ of animal virology, but with the increased recognition of their role in human diseases together with the results generated by the application of molecular techniques, the Bunyaviridae have achieved greater respectability. Rift Valley fever, Crimean-Congo haemorrhagic fever and California encephalitis viruses are serious human pathogens that are classified in the family Bunyaviridae. In the tropics febrile illnesses are often diagnosed under the ‘great umbrella’ (Downs, 1975) of malaria and treated as such; in fact many cases are probably caused by members of the Bunyaviridae, although true diagnosis is rarely achieved (Shope, 1985). Hantaan and related viruses, the causative agents of haemorrhagic fever with renal syndrome, are now recognized as belonging to the Bunyaviridae (Schmaljohn & Dalrymple, 1983) and cause a severe haemorrhagic disease with significant mortality throughout Asia, especially in China.
© Society for General Microbiology Ltd 1990 | Published by the Microbiology Society
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