1887

Abstract

Epidemiological investigation of a new incident of transmissible mink encephalopathy (TME) in Stetsonville, Wisconsin, U.S.A. in 1985 revealed that the mink rancher had never fed sheep products to his mink but did feed them large amounts of products from fallen or sick dairy cattle. To investigate the possibility that this occurrence of TME may have resulted from exposure to infected cattle, two Holstein bull calves were injected intracerebrally with mink brain from the Stetsonville ranch. Each bull developed a fatal spongiform encepha-lopathy 18 and 19 months after inoculation, respectively, and both bovine brains passaged back into mink were highly pathogenic by either intracerebral or oral inoculation. These results suggest the presence of a previously unrecognized scrapie-like infection in cattle in the United States.

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1991-03-01
2024-04-20
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References

  1. Aiken J. M., Williamson J. L., Marsh R. F. 1989; Evidence for mitochondrial involvement in scrapie infection. Journal of Virology 63:1686–1694
    [Google Scholar]
  2. Brown P., Liberski P. P., Wolf A., Gajdusek D. C. 1990; Resistance of scrapie infectivity to steam autoclaving after formaldehyde fixation and limited survival after washing at 360 °C: practical and theoretical implications. Journal of Infectious Diseases 161:467–472
    [Google Scholar]
  3. Burger D., Hartsough G. R. 1965; Encephalopathy of mink. II. Experimental and natural transmission. Journal of Infectious Diseases 115:393–399
    [Google Scholar]
  4. Eckroade R. B., Zu Rhein G. M., Marsh R. F., Hanson R. P. 1970; Transmissible mink encephalopathy: experimental transmission to the squirrel monkey. Science 169:1088–1090
    [Google Scholar]
  5. Eckroade R. J., Zu Rhein G. M., Hanson R. P. 1973; Transmissible mink encephalopathy in carnivores: clinical, light and electron microscopic studies in raccoons, skunks and ferrets. Journal of Wildlife Diseases 9:229–240
    [Google Scholar]
  6. Eckroade R. J., Zu Rhein G. M., Hanson R. P. 1979; Experimental transmissible mink encephalopathy: brain lesions and their sequential development in mink. In Slow Transmissible Diseases of the Nervous System vol 1 pp 409–449 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
  7. Fraser H., McConnell I., Wells G. A. H., Dawson M. 1988; Transmission of bovine spongiform encephalopathy to mice. Veterinary Record 123:472
    [Google Scholar]
  8. Hadlow W. J., Race R. E., Kennedy R. C. 1986; Experimental infection of sheep and goats with transmissible mink encephalopathy virus. Canadian Journal of Veterinary Research 51:135–144
    [Google Scholar]
  9. Hanson R. P., Eckroade R. J., Marsh R. F., Zu Rhein G. M., Kanitz C. L., Gustafson D. P. 1971; Susceptibility of mink to sheep scrapie. Science 172:859–861
    [Google Scholar]
  10. Hartsough G. R., Burger D. 1965; Encephalopathy of mink. I. Epizootiologic and clinical observations. Journal of Infectious Diseases 115:387–392
    [Google Scholar]
  11. Hilmert H., Diringer H. 1984; A rapid and efficient method to enrich SAF-protein from scrapie brains of hamsters. Bioscience Reports 4:165–170
    [Google Scholar]
  12. Marsh R. F. 1976; Subacute spongiform encephalopathies. In Slow Virus Diseases of Animals and Man pp 359–380 Edited by Kimberlin R. H. New York: Elsevier;
    [Google Scholar]
  13. Marsh R. F., Hanson R. P. 1969; Physical and chemical properties of the transmissible mink encephalopathy agent. Journal of Virology 3:176–181
    [Google Scholar]
  14. Marsh R. F., Hanson R. P. 1979; On the origin of transmissible mink encephalopathy. In Slow Transmissible Diseases of the Nervous System vol 1 pp 451–460 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
  15. Marsh R. F., Hartsough G. R. 1985; Is there a scrapie-like disease in cattle?. In Proceedings of the 89th Annual Meeting of the US Animal Health Association pp 8–9
    [Google Scholar]
  16. Marsh R. F., Hartsough G. R. 1988; Evidence that transmissible mink encephalopathy results from feeding infected cattle. In Proceedings of the IV International Congress on Fur Animal Production pp 204–207 Edited by Murphy B. D., Hunter D. B. Toronto: Canada Mink Breeders Association;
    [Google Scholar]
  17. Marsh R. F., Kimberlin R. H. 1975; Comparison of scrapie and transmissible mink encephalopathy in hamsters. II. Clinical signs, pathology, and pathogenesis. Journal of Infectious Diseases 131:104110
    [Google Scholar]
  18. Marsh R. F., Burger D., Eckroade R., Zu Rhein G. M., Hanson R. P. 1969; A preliminary report on the experimental host range of the transmissible mink encephalopathy agent. Journal of Infectious Diseases 120:713–719
    [Google Scholar]
  19. Taylor M. D., Dickinson A. G., Fraser H., Marsh R. F. 1986; Evidence that transmissible mink encephalopathy agent is biologically inactive in mice. Neuropathology and Applied Neurobiology 12:207–215
    [Google Scholar]
  20. Wells G. A. H., Scott A. C., Johnson C. T., Gunning R. F., Hancock R. D., Jeffrey M., Dawson M., Bradley R. 1987; A novel progressive spongiform encephalopathy in cattle. Veterinary Record 121:419–420
    [Google Scholar]
  21. Wilesmith J. W., Wells G. A. H., Cranwill M. P., Ryan J. B. M. 1988; Bovine spongiform encephalopathy: epidemiologic studies. Veterinary Record 123:638–644
    [Google Scholar]
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