f Induction of chromosome abnormalities in mouse and human epidermal keratinocytes by the human papillomavirus type 16 E7 oncogene
- Authors: Takashi Hashida, Shigeru Yasumoto
- J. Gen. Virol., July 1991 72: 1569-1577, doi: 10.1099/0022-1317-72-7-1569
- Subject: Animal
- Published Online:
Cytogenetic abnormalities associated with human papillomavirus (HPV) type 16 were studied using primary human and mouse epidermal keratinocytes. The E7 transforming gene of HPV-16 was found to induce chromosome duplication in epidermal keratinocytes; little or no detectable chromosome disorganization was associated with the function of the E6 gene. These results suggest that the E7 gene-linked cytogenetic effect reflects HPV-16-associated pathogenicity in the early phase of transformation.
© Society for General Microbiology 1991 | Published by the Microbiology Society
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