Induction of chromosome abnormalities in mouse and human epidermal keratinocytes by the human papillomavirus type 16 E7 oncogene
Hashida, Takashi and Yasumoto, Shigeru,, 72, 1569-1577 (1991),
doi = https://doi.org/10.1099/0022-1317-72-7-1569,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Cytogenetic abnormalities associated with human papillomavirus (HPV) type 16 were studied using primary human and mouse epidermal keratinocytes. The E7 transforming gene of HPV-16 was found to induce chromosome duplication in epidermal keratinocytes; little or no detectable chromosome disorganization was associated with the function of the E6 gene. These results suggest that the E7 gene-linked cytogenetic effect reflects HPV-16-associated pathogenicity in the early phase of transformation.,
language=,
type=