Nuclear localization of dengue 2 virus core protein detected with monoclonal antibodies
Bulich, R. and Aaskov, J. G.,, 73, 2999-3003 (1992),
doi = https://doi.org/10.1099/0022-1317-73-11-2999,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Anti-dengue 2 virus core protein monoclonal antibodies (MAbs) reacted with antigens in the cytoplasm and in, or on, the nucleus of dengue 2 and dengue 4, but not dengue 1, dengue 3, Kunjin or Murray Valley encephalitis virus-infected cells. These MAbs also reacted with the core protein from dengue 1, 2 and 4 virions in Western blots. The antigens detected by these MAbs could not be detected in uninfected or heat-shocked cells, but were first detected in infected cells approximately 32 h post-infection. PEPSCAN epitope mapping suggested that all the MAbs react with a region of the dengue 2 virus core protein (9RNTPFNMLKRE19) which is adjacent to a putative nuclear localization sequence (6KKAR9) and spans a possible second site for the initiation of synthesis of core protein (12PFN↓MLKR18).,
language=,
type=