RT Journal Article SR Electronic(1) A1 Li, Xing Shan A1 Zhao, Cui Yeng A1 Gao, Hui Ming A1 Zhang, Yu Qi A1 Ishida, Masatoshi A1 Kanegae, Yumi A1 Endo, Atsushi A1 Nerome, Reiko A1 Omoe, Katsuhiko A1 Nerome, KuniakiYR 1992 T1 Origin and evolutionary characteristics of antigenic reassortant influenza A (H1N2) viruses isolated from man in China JF Journal of General Virology, VO 73 IS 6 SP 1329 OP 1337 DO https://doi.org/10.1099/0022-1317-73-6-1329 PB Microbiology Society, SN 1465-2099, AB During the 1988/1989 influenza season, five antigenic reassortant influenza A (H1N2) viruses not previously isolated from man were isolated in Hebei province, People’s Republic of China. All isolates contained haemagglutinins (HAs) and neuraminidases (NAs) which were antigenically similar to those of the recent Russian (H1N1) and Hong Kong influenza A (H3N2) viruses, respectively. The results of antigenic and nucleotide sequence analyses revealed that the genes encoding the polymerase, nucleoprotein, NA, matrix and non-structural proteins of the reassortant A/Hebei/24/89 (H1N2) virus were derived from the H3N2 parent virus, whereas its HA gene was from the H1N1 parent virus. The nucleotide sequences of the HA (encoding the HA1 subunit) and NA genes of the reassortant viruses were also determined. Phylogenetic trees constructed from these data by the neighbour-joining method revealed that the HA gene of the reassortant virus was closely related to those of recent human H1N1 viruses, whereas the NA gene was related to a recent human Hong Kong (H3N2) virus lineage., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-73-6-1329