@article{mbs:/content/journal/jgv/10.1099/0022-1317-73-8-2167, author = "Barnett, Barbara C. and Dolan, Aidan and Telford, Elizabeth A. R. and Davison, Andrew J. and McGeoch, Duncan J.", title = "A novel herpes simplex virus gene (UL49A) encodes a putative membrane protein with counterparts in other herpesviruses", journal= "Journal of General Virology", year = "1992", volume = "73", number = "8", pages = "2167-2171", doi = "https://doi.org/10.1099/0022-1317-73-8-2167", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-73-8-2167", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Comparative analysis of DNA sequences located between the coding regions of genes UL49 and UL50 of herpes simplex virus types 1 and 2 (HSV-1 and -2) has revealed a small open reading frame (ORF) of 91 and 87 codons respectively with the characteristics of a genuine protein-coding region. The predicted protein products are clearly related and exhibit features of membrane-inserted proteins, with potential N-proximal signal peptides and C-proximal membrane anchor regions. Counterparts are present in the other sequenced alphaherpesviruses, namely varicella-zoster virus (a previously undescribed gene, 9A) and equine herpesvirus type 1 (gene 10), in the betaherpesvirus human cytomegalovirus (gene UL73) and in the gammaherpesvirus Epstein-Barr virus (gene BLRF1). Therefore, we consider that this ORF represents an additional HSV gene (UL49A) with counterparts in all sequenced alpha-, beta- and gammaherpesviruses.", }