f New observations on antigenic diversification of RNA viruses. Antigenic variation is not dependent on immune selection
- Authors: Esteban Domingo, Juana Díez, Miguel A. Martínez†, Javier Hernández, Africa Holguín, Belén Borrego, Mauricio G. Mateu
- First Published Online: 01 October 1993, Journal of General Virology 74: 2039-2045, doi: 10.1099/0022-1317-74-10-2039
- Subject: Review Article
- Issue Published:
Recent results have revealed novel features in the process of antigenic diversification of FMDV. (i) Antigenic variation is not necessarily the result of immune selection. (ii) Single, critical amino acid replacements may either have a minor effect on antigenic specificity or cause a drastic antigenic change affecting many epitopes on an antigenic site. (iii) The effect of such a critical replacement may be suppressed by additional substitutions at neighbouring sites. (iv) Antigenic diversification does not necessarily involve net accumulation of amino acid substitutions over time. We review evidence that some of these features apply also to other riboviruses and retroviruses. A model is proposed to relate antigenic variation without immune selection to the quasispecies structure of RNA virus populations.
Present address: Laboratoire de Rétrovirologie Moléculaire, Institut Pasteur, 75724 Paris Cédex 15, France.
© Society for General Microbiology 1993 | Published by the Microbiology Society
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