%0 Journal Article %A Ellinger, K. %A Neipel, F. %A FoĆ -Tomasi, L. %A Campadelli-Fiume, G. %A Fleckenstein, B. %T The glycoprotein B homologue of human herpesvirus 6 %D 1993 %J Journal of General Virology, %V 74 %N 3 %P 495-500 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-74-3-495 %I Microbiology Society, %X The gene for the homologue of herpesvirus glycoprotein B (gB) has been identified in the genome of human herpesvirus 6 (HHV-6), strain U1102, and the nucleotide sequence was determined. The open reading frame encodes a protein of 830 amino acids (93.2K) with the characteristics of a transmembrane glycoprotein and close similarity to the gp58/116 complex of human cytomegalovirus (HCMV). Monoclonal antibodies 2D10 and 2B9 have been shown previously to react with an HHV-6 glycoprotein of apparent M r 112K, and its proteolytic cleavage products of M r 64K and 58K. We show that both monoclonal antibodies detect prokaryotically expressed carboxy-terminal fragments of the HHV-6 gB homologue. This indicates that the HHV-6 gB homologue is probably processed by proteolytic cleavage similar to its equivalents in HCMV and various other herpesviruses. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-74-3-495