1887

Abstract

A newly identified hantavirus, tentatively called Four Corners virus (FCV), was found to be the aetiological agent of a 1993 outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States. Immunodominant epitopes of 43 and 31 amino acids were identified in the nucleocapsid protein and G1 glycoprotein, respectively. The G1 genes of different hantaviruses are highly divergent, suggesting that geographically diverse FCVs might fail to cross-react owing to antigenic drift. We now show that the immunodominant epitope of G1 is conserved among 18 FCVs from a broad geographical area, despite extensive nucleotide sequence heterogeneity. Antibodies from all 45 HPS patients, separated by more than 3000 km were shown to be reactive with the dominant G1 epitope. Evidence for limited cross-reactivity between the G1 antigen of a novel hantavirus of the cotton rat and that of FCV is presented.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-75-11-2881
1994-11-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/75/11/JV0750112881.html?itemId=/content/journal/jgv/10.1099/0022-1317-75-11-2881&mimeType=html&fmt=ahah

References

  1. Antic D., Kang C. Y., Spik K., Schmaljohn C., Vapalahti O., Vaheri A. 1992; Comparison of the deduced gene products of the L, M, and S genome segments of hantaviruses. Virus Research 24:35–46
    [Google Scholar]
  2. Arikawa J., Schmaljohn A. L., Dalrymple J. M., Schmaljohn C. S. 1989; Characterization of Hantaan virus envelope glycoprotein antigenic determinants defined by monoclonal antibodies. Journal of General Virology 70:615–624
    [Google Scholar]
  3. Arikawa J., Lapenotiere H. F., Iacono-Conners L., Wang M. L., Schmaljohn C. S. 1990; Coding properties of the S and the M genome segments of Sapporo rat virus: comparison to other causative agents of hemorrhagic fever with renal syndrome. Virology 176:114–125
    [Google Scholar]
  4. Arikawa J., Yao J. -S., Yoshimatsu K., Takashima I., Hashimoto N. 1992; Protective role of antigenic sites on the envelope protein of Hantaan virus defined by monoclonal antibodies. Archives of Virology 126:271–281
    [Google Scholar]
  5. Baker R. H. 1968; Habitats and distribution. In Biology of Peromyscus (Rodentia)98–126 King J. A. Edited by Lawrence, Kansas: Special Publication of the American Society of Mammalo-gists;
    [Google Scholar]
  6. Centers for Disease Control and Prevention 1993a; Outbreak of acute illness -Southwestern United States. Morbidity and Mortality Weekly Reports 42421–424
    [Google Scholar]
  7. Centers for Disease Control and Prevention 1993b; Update: outbreak of hantavirus infection -Southwestern United States. Morbidity and Mortality Weekly Reports 42495–496
    [Google Scholar]
  8. Centers for Disease Control and Prevention 1994a; Update: hantavirus pulmonary syndrome -United States 1993. Morbidity and Mortality Weekly Reports 4345–48
    [Google Scholar]
  9. Centers for Disease Control and Prevention 1994b; Newly identified hantavirus -Florida. Morbidity and Mortality Weekly Reports 1994 4399105
    [Google Scholar]
  10. Childs J. E., Ksiazek T. G., Spiropoulou C. F., Krebs J. W., Morzunov S., Maupin G. O., Gage K. L., Rollin P. E., Sarisky J., Enscore R. E., Frey J. K., Peters C. J., Nichol S. T. 1994; Serologic and genetic identification of Peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States. Journal of Infectious Diseases 169:1271–1280
    [Google Scholar]
  11. Chu Y. K., Rossi C., Leduc J. W., Lee H. W., Schmaljohn C. S., Dalrymple J. M. 1994; Serological relationships among viruses in the Hantavirus genus, family bunyaviridae. Virology 198:196–204
    [Google Scholar]
  12. Duchin J. S., Koster F. T., Peters C. J., Simpson G. L., Tempest B., Zaki S. R., Ksiazek T. G., Rollin P., Nichol S., Umland E., Moolenaar R. L., Reef S. E., Nolte K. B., Gallaher M. M., Butler J. C., Breiman R. F.The Hantavirus Study Group 1994; Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. New England Journal of Medicine 330949–955
    [Google Scholar]
  13. Elliott R. M., Schmaljohn C. S., Collett M. S. 1991; Bunyavirus genome structure and gene expression. Current Topics in Microbiology and Immunology 169:91–141
    [Google Scholar]
  14. Hillis D. M., Huelsenbeck J. P., Cunningham C. W. 1994; Application and accuracy of molecular phylogenies. Science 264:671–677
    [Google Scholar]
  15. Hjelle B., Jenison S., Torrez-Martinez N., Yamada T., Nolte K., Zumwalt R., Macinnes K., Myers G. 1994a; A novel hantavirus associated with an outbreak of fatal respiratory disease in the southewestern United States: evolutionary relationships to known hantaviruses. Journal of Virology 68:592–596
    [Google Scholar]
  16. Hjelle B., Jenison S., Mertz G., Koster F., Foucar K. 1994b; Emergence of hantavirus disease in the southwestern United States. Western Journal of Medicine in press
    [Google Scholar]
  17. Hjelle B., Spiropoulou C. F., Torrez-Martinez N., Morzunov S., Peters C. J., Nichol S. T. 1994c; Detection of Muerto Canyon virus RNA in peripheral blood mononuclear cells from patients with hantavirus pulmonary syndrome. Journal of Infectious Diseases in press
    [Google Scholar]
  18. Jenison S., Yamada T., Morris C., Anderson B., Torrez-Martinez N., Keller N., Hjelle B. 1994; Characterization of human antibody responses to Four Corners hantavirus infections among patients with hantavirus pulmonary syndrome. Journal of Virology 68:3000–3006
    [Google Scholar]
  19. Koerner T. J., Hill J. E., Myers A. M., Tzagoloff A. 1991; High expression vectors with multiple cloning sites for construction of trpE fusion proteins: pATH vectors. Methods in Enzymology 194:477–490
    [Google Scholar]
  20. Lundkvist Å., Niklasson B. 1992; Bank vole monoclonal antibodies against Puumala virus envelope glycoproteins: identification of epitopes involved in neutralization. Archives of Virology 126:93–105
    [Google Scholar]
  21. Maddison W. P., Maddison D. R. 1992; MacClade: analysis of phylogeny and character evolution. Version 3.0 (computer program). Sinauer Associates, Sunderland, Massachusetts; U.S.A.:
    [Google Scholar]
  22. Nerurkar V. R., Song K. -J., Song J. -W., Nagle J. W., Hjelle B., Jenison S., Yanagihara R. 1994; Genetic evidence for a hantavirus enzootic in deer mice (Peromyscus maniculatus) a decade before the recognition of hantaviral pulmonary syndrome. Virology in press
    [Google Scholar]
  23. Nichol S. T., Spiropoulou C. F., Morzunov S., Rollin P. E., Ksiazek T. G., Feldmann H., Sanchez A., Childs J., Zaki S., Peters C. J. 1993; Genetic identification of a novel hantavirus associated with an outbreak of acute respiratory illness in the southwestern United States. Science 262:914–917
    [Google Scholar]
  24. Parrington M. A., Lee P. W., Kang C. Y. 1991; Molecular characterization of the Prospect Hill virus M RNA segment: a comparison with the M RNA segments of other hantaviruses. Journal of General Virology 72:1845–1854
    [Google Scholar]
  25. Schmaljohn C, Schmaljohn A. L., Dalrymple J. M. 1987; Hantaan virus M RNA: coding strategy, nucleotide sequence, and gene order. Virology 157:31–39
    [Google Scholar]
  26. Schmaljohn C. S., Arikawa J., Hasty S. E., Rasmussen L., Lee H. -W., Lee P. W., Dalrymple J. M. 1988; Conservation of antigenic properties and sequences encoding the envelope proteins of prototype Hantaan virus and two virus isolates from Korean haemorrhagic fever patients. Journal of General Virology 64:3162–3170
    [Google Scholar]
  27. Swofford D. L. 1991; PAUP: Phylogenetic Analysis Using Parsimony. Version 3.1.1. (Computer program). Illinois Natural History Survey Champaign, Illinois; U.S.A.:
    [Google Scholar]
  28. Vapalahti O., Kallio-Kokko H., Salonen E. M., Brummer-Korvenkontio M., Vaheri A. 1992; Cloning and sequencing of Puumala virus Sotkamo strain S and M segments: evidence for strain variation in hantaviruses and expression of the nucleocapsid protein. Journal of General Virology 73:829–838
    [Google Scholar]
  29. Wang M., Pennock D. G., Spik K. W., Schmaljohn C. S. 1993a; Epitope mapping studies with neutralizing and nonneutralizing monoclonal antibodies to the G1 and G2 envelope glycoproteins of Hantaan virus. Virology 197:757–766
    [Google Scholar]
  30. Wang M., Rossi C., Schmaljohn C. S. 1993b; Expression of nonconserved regions of the S genome segments of three hantaviruses: evaluation of the expressed polypeptides for diagnosis of haemorrhagic fever with renal syndrome. Journal of General Virology 74:1115–1124
    [Google Scholar]
  31. Wilson C., Hjelle B., Jenison S. 1994; A probable case of hantavirus pulmonary syndrome that occurred in New Mexico in 1975. Annals of Internal Medicine 120:813
    [Google Scholar]
  32. Xiao S. -Y., Liang M., Schmaljohn C. S. 1993; Molecular and antigenic characterization of HV114, a hantavirus isolated from a patient with haemorrhagic fever with renal syndrome in China. Journal of General Virology 74:1657–1659
    [Google Scholar]
  33. Xiao S. -Y., Leduc J. W., Chu Y. -K., Schmaljohn C. S. 1994; Phylogenetic analysis of virus isolates of the genus hantavirus, family bunyaviridae. Virology 198:205–217
    [Google Scholar]
  34. Yanagihara R., Gajdusek D. C. 1987; Hemorrhagic fever with renal syndrome: global epidemiology and ecology of hantavirus infections. In Medical Virology VI171–214 De la Maza L. M. Edited by Washington, D.C: Elsevier Science Publishers;
    [Google Scholar]
  35. Yoshimatsu K., Yoo Y. -C., Yoshida R., Ishihara C., Azuma I., Arikawa J. 1993; Protective immunity of Hantaan virus nucleocapsid and envelope protein studied using baculovirus-expressed proteins. Archives of Virology 130:365–376
    [Google Scholar]
  36. Zöller L., Yang S., Gott S. P., Bautz E. K. F., Darai G. 1993; Use of recombinant nucleocapsid proteins of the Hantaan and nephropathia epidemica serotypes of hantaviruses as immuno-diagnostic antigens. Journal of Medical Virology 39:200–207
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-75-11-2881
Loading
/content/journal/jgv/10.1099/0022-1317-75-11-2881
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error