f Delineation of a Sequence Required for Nuclear Localization of the Protein Encoded by Varicella-zoster Virus Gene 61
- Authors: David Stevenson, Kathryn L. Colman, Andrew J. Davison
- First Published Online: 01 November 1994, Journal of General Virology 75: 3229-3233, doi: 10.1099/0022-1317-75-11-3229
- Subject: Animal
- Issue Published:
All characterized alphaherpesviruses encode a protein whose N-terminal region contains a novel zinc-binding motif, the C3HC4 domain. Homology between the different proteins is in general limited to key residues in this domain. In order to identify a separate landmark site in the C3HC4 protein encoded by varicella-zoster virus gene 61, namely the region required for nuclear localization, we have analysed a range of mutants in transient expression and immunofluorescence experiments. A basic region (RGAKRR) at residues 387 to 392 was found to be required for nuclear localization, and residues 390 and 391 were critical.
© Society for General Microbiology Ltd 1994 | Published by the Microbiology Society
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/content/journal/jgv/10.1099/0022-1317-75-11-3229dcterms_title,dcterms_subject-pub_serialIdent:journal/jgv AND -contentType:BlogPost104
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