Delineation of a Sequence Required for Nuclear Localization of the Protein Encoded by Varicella-zoster Virus Gene 61
Stevenson, David and Colman, Kathryn L. and Davison, Andrew J.,, 75, 3229-3233 (1994),
doi = https://doi.org/10.1099/0022-1317-75-11-3229,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= All characterized alphaherpesviruses encode a protein whose N-terminal region contains a novel zinc-binding motif, the C3HC4 domain. Homology between the different proteins is in general limited to key residues in this domain. In order to identify a separate landmark site in the C3HC4 protein encoded by varicella-zoster virus gene 61, namely the region required for nuclear localization, we have analysed a range of mutants in transient expression and immunofluorescence experiments. A basic region (RGAKRR) at residues 387 to 392 was found to be required for nuclear localization, and residues 390 and 391 were critical.,
language=,
type=