f Rotavirus Causes Selective Vimentin Reorganization in Monkey Kidney CV-1 Cells
- Authors: Katarzyna Weclewicz, Krister Kristensson, Lennart Svensson
- First Published Online: 01 November 1994, Journal of General Virology 75: 3267-3271, doi: 10.1099/0022-1317-75-11-3267
- Subject: Animal
- Issue Published:
The effect of rotavirus infection on cytoskeletal organization was examined in cultured African green monkey kidney (CV-1) cells. Rhesus rotavirus caused significant and selective changes in the organization of the vimentin filament network without having any effect on microtubules or actin. Double-immunofluorescence studies showed that at 6 h post-infection, and in the absence of cytopathic effect, the normal arrays of vimentin fibres radiating from multiple sites around the nucleus were lost. Vimentin fibres became irregularly distributed in the cytoplasm and were totally disrupted in the later stages of infection. Vimentin reorganization occurred independent of extracellular Ca2+ levels.
© Society for General Microbiology Ltd 1994 | Published by the Microbiology Society
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