Serological differentiation of human papillomavirus types 11, 16 and 18 using recombinant virus-like particles
Rose, Robert C. and Bonnez, William and Da Rin, Caroline and McCance, Dennis J. and Reichman, Richard C.,, 75, 2445-2449 (1994),
doi = https://doi.org/10.1099/0022-1317-75-9-2445,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= The L1 major capsid protein-coding sequences of human papillomavirus (HPV) types 11, 16 and 18 were expressed in the baculovirus system. Virus-like particles (VLPs) were purified from recombinant-infected Spodoptera frugiperda Sf9 cells and cell-free culture supernatants. Rabbits immunized with purified VLPs developed antibodies that reacted only with the specific VLP type used as the immunogen. In addition, rabbit antibodies raised against infectious HPV-11 virions only reacted with HPV-11 L1 VLPs and not with VLPs derived from either HPV-16 or HPV-18. These results suggest that HPV-11, HPV-16 and HPV-18 virions are antigenically distinct from one another. This observation should be considered in future studies of immune responses to HPV.,
language=,
type=